Thaksin University has established cooperation with various foreign universities and educational institutions in Southeast Asia, Asia, Europe and South America in order to develop its educational standards on par with the counterparts. Relationship has been fostered for the objectives of shared development efforts in instruction, curriculum development, research, personnel development, and student and cultural exchange programs. Participating universities and institutions include the following:
- Malaysia 
· Universiti Malaysia Perlis (UniMAP) 
· Universiti Sains Malaysia 
· Universiti Pendidikan Sultan Idris
· Universiti Kebangsaan Malaysia
- The Philippines
· San Beda College IMT-GT UNINET
· Cooperation between Thailand, Malaysia and Indonesia
- Lao People's Democratic Republic
· Soutsaka College of Management and Technology 
- People’s Republic of China
· Harbin Engineering University 
· Yunnan College of Business Management 
· Guangxi Normal University 
· Human University 
· Chongqing University
- Japan
· Yamaguchi University 
· Josai University
- Educational Corporation Taiwan
· Kun Shan University 
· Tzu Chi University
- France
· Centre de cooperation international en recherché agronomique pour le development (CIRAD)
- Australia
· The Thai Language School of Melbourne Incorporated
- Brazil
· Federal University of Grande Dourados